InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pmvk

Summary

InnateDB Gene

IDBG-164713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pmvk

Gene Name

phosphomevalonate kinase

Synonyms

1110011E12Rik; 2900002L22Rik; AV001327; PMK; PMKA; PMKASE

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027952

Encoded Proteins

IDBP-164715

phosphomevalonate kinase

IDBP-266733

phosphomevalonate kinase

IDBP-787725

phosphomevalonate kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163344:
This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:89459118-89469013

Strand

Forward strand

Band

Transcripts

ENSMUST00000029564	ENSMUSP00000029564
ENSMUST00000107410	ENSMUSP00000103033
ENSMUST00000184515	ENSMUSP00000139116

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004631	phosphomevalonate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0016310	phosphorylation
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0070723	response to cholesterol