InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnn3

Summary

InnateDB Gene

IDBG-164740.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnn3

Gene Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000794

Encoded Proteins

IDBP-164742

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143603:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:89520164-89672072

Strand

Forward strand

Band

Transcripts

ENSMUST00000000811	ENSMUSP00000000811
ENSMUST00000124584

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005516	calmodulin binding
GO:0015269	calcium-activated potassium channel activity
GO:0016286	small conductance calcium-activated potassium channel activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006813	potassium ion transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030175	filopodium
GO:0031594	neuromuscular junction
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0044297	cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000143603

View Gene Order

ENSBTAG00000018249

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75896

Ca2+ activated K+ channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.120250

RefSeq

NM_080466

OMIM

CCDS

CCDS38495

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas