Version 5.4
Mus musculus Gene: Cryaa
Summary
InnateDB Gene IDBG-164758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cryaa
Gene Name crystallin, alpha A
Synonyms Acry-1; Crya-1; Crya1; DAcry-1; lop18
Species Mus musculus
Ensembl Gene ENSMUSG00000024041
Encoded Proteins
IDBP-164760
crystallin, alpha A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein (sHSP) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. In mouse, deficiency in this gene is associated with smaller lenses and eyes and with increasing lens opacity with age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:31677933-31681722
Strand Forward strand
Band B1
Transcripts
ENSMUST00000019192 ENSMUSP00000019192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002088 lens development in camera-type eye
GO:0002089 lens morphogenesis in camera-type eye
GO:0006457 protein folding
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization
GO:0007015 actin filament organization
GO:0007017 microtubule-based process
GO:0007021 tubulin complex assembly
GO:0007601 visual perception
GO:0010288 response to lead ion
GO:0010629 negative regulation of gene expression
GO:0030307 positive regulation of cell growth
GO:0032387 negative regulation of intracellular transport
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048596 embryonic camera-type eye morphogenesis
GO:0051260 protein homooligomerization
GO:0051384 response to glucocorticoid
GO:0060561 apoptotic process involved in morphogenesis
GO:0070141 response to UV-A
GO:0070309 lens fiber cell morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160202
View Gene Order
ENSBTAG00000003134
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt P24622
TrEMBL Q546L9 Q8VBT8
UniProt Splice Variant
Entrez Gene 12954
UniGene Mm.1228
RefSeq NM_001278569 NM_013501 XM_006523574
OMIM
CCDS CCDS37551
HPRD
IMGT
MGI ID MGI:88515
MGI Symbol Cryaa
EMBL AF414445 AF414446 AF414447 AF414448 AF414449 AF414450 AF414451 AF414452 AF414453 AJ310308 BC085170 CH466640 J00375 J00376 V00730
GenPept AAA37469 AAA37470 AAA37471 AAH85170 AAL40721 AAL40722 AAL40723 AAL40724 AAL40725 AAL40726 AAL40727 AAL40728 AAL40729 CAA24108 CAA24109 CAC35974 EDL40342
RNA Seq Atlas 12954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca