Version 5.4
Mus musculus Gene: Srd5a1
Summary
InnateDB Gene IDBG-164887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srd5a1
Gene Name steroid 5 alpha-reductase 1
Synonyms 0610031P22Rik; 4930435F02Rik; S5AR 1; Srd5a-1
Species Mus musculus
Ensembl Gene ENSMUSG00000021594
Encoded Proteins
IDBP-164889
steroid 5 alpha-reductase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145545:
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:69573449-69611442
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000091514 ENSMUSP00000089097
ENSMUST00000059235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0047751 cholestenone 5-alpha-reductase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006702 androgen biosynthetic process
GO:0007548 sex differentiation
GO:0008202 steroid metabolic process
GO:0030154 cell differentiation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145545
View Gene Order
ENSBTAG00000015478
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_220332
Androgen biosynthesis pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
KEGG
mmu00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11059
Androgen biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_208375
Metabolism of steroid hormones and vitamin D pathway
REACT_219139
Metabolism pathway
REACT_212422
Androgen biosynthesis pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q68FF9
TrEMBL
UniProt Splice Variant
Entrez Gene 78925
UniGene Mm.451912
RefSeq NM_175283
OMIM
CCDS CCDS26624
HPRD
IMGT
MGI ID MGI:98400
MGI Symbol Srd5a1
EMBL BC079863 BC094503
GenPept AAH79863 AAH94503
RNA Seq Atlas 78925

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca