InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pcnt

Summary

InnateDB Gene

IDBG-164991.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcnt

Gene Name

pericentrin (kendrin)

Synonyms

AW476095; C86676; KEN; kendrin; m239Asp; m275Asp; Pcnt2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001151

Encoded Proteins

IDBP-164993

pericentrin (kendrin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160299:
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:76351254-76442912

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001179

ENSMUSP00000001179

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0007051	spindle organization
GO:0021696	cerebellar cortex morphogenesis
GO:0021772	olfactory bulb development
GO:0035108	limb morphogenesis
GO:0035264	multicellular organism growth
GO:0042384	cilium assembly
GO:0043066	negative regulation of apoptotic process
GO:0048854	brain morphogenesis
GO:0061351	neural precursor cell proliferation
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0000242	pericentriolar material
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005814	centriole
GO:0005815	microtubule organizing center
GO:0016020	membrane
GO:0031514	motile cilium
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body
GO:0045171	intercellular bridge