InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Golga5

Summary

InnateDB Gene

IDBG-165832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Golga5

Gene Name

golgi autoantigen, golgin subfamily a, 5

Synonyms

Ret-II

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021192

Encoded Proteins

IDBP-165834

golgi autoantigen, golgin subfamily a, 5

IDBP-713121

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066455:
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. [provided by RefSeq, Feb 2010]
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:102469134-102497902

Strand

Forward strand

Band

Transcripts

ENSMUST00000021609	ENSMUSP00000021609
ENSMUST00000179218	ENSMUSP00000137305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007030	Golgi organization
GO:0048193	Golgi vesicle transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031985	Golgi cisterna

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000066455

View Gene Order

ENSBTAG00000004598

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.273370

RefSeq

NM_001199004 NM_013747 XM_006515935

OMIM

CCDS

CCDS36526

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas