Version 5.4
Mus musculus Gene: Slc6a18
Summary
InnateDB Gene IDBG-166005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc6a18
Gene Name solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms B0AT3; D630001K16Rik; Xt2; Xtrp2
Species Mus musculus
Ensembl Gene ENSMUSG00000021612
Encoded Proteins
IDBP-166007
solute carrier family 6 (neurotransmitter transporter), member 18
IDBP-261870
solute carrier family 6 (neurotransmitter transporter), member 18
IDBP-261872
solute carrier family 6 (neurotransmitter transporter), member 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164363:
The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:73661750-73678023
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000022105 ENSMUSP00000022105
ENSMUST00000109680 ENSMUSP00000105302
ENSMUST00000109679 ENSMUSP00000105301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005515 protein binding
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006810 transport
GO:0006836 neurotransmitter transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164363
View Gene Order
ENSBTAG00000012559
Not yet available
Pathways
NETPATH
REACTOME
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_253228
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_230460
Amino acid transport across the plasma membrane pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O88576
TrEMBL
UniProt Splice Variant
Entrez Gene 22598
UniGene Mm.30370
RefSeq NM_001168643 NM_001168644 NM_001040692 NM_001136087 NM_001168645 NM_001168646
OMIM
CCDS CCDS49312 CCDS36727 CCDS49311
HPRD
IMGT
MGI ID MGI:1336892
MGI Symbol Slc6a18
EMBL AF075262 AF075263 AF075264 AF075265 AF075266 AF075267 BC010748
GenPept AAC27757 AAC27758 AAC27759 AAC27760 AAC27761 AAC27762 AAH10748
RNA Seq Atlas 22598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca