Version 5.4
Mus musculus Gene: Igfbp5
Summary
InnateDB Gene IDBG-166131.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igfbp5
Gene Name insulin-like growth factor binding protein 5
Synonyms AI256729; AW208790; IGFBP-5; IGFBP-5P
Species Mus musculus
Ensembl Gene ENSMUSG00000026185
Encoded Proteins
IDBP-166133
insulin-like growth factor binding protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115461:
Gene Information
Type Protein coding
Genomic Location Chromosome 1:72857932-72874884
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000027377 ENSMUSP00000027377
ENSMUST00000137339
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 0
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0031994 insulin-like growth factor I binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0006006 glucose metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0014912 negative regulation of smooth muscle cell migration
GO:0017148 negative regulation of translation
GO:0030336 negative regulation of cell migration
GO:0031069 hair follicle morphogenesis
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0042593 glucose homeostasis
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0044342 type B pancreatic cell proliferation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048630 skeletal muscle tissue growth
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051146 striated muscle cell differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060056 mammary gland involution
GO:0071320 cellular response to cAMP
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005576 extracellular region
GO:0016942 insulin-like growth factor binding protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115461
View Gene Order
ENSBTAG00000007062
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
REACT_206584
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_213782
Metabolism of proteins pathway
KEGG
INOH
INOH website
IGF1 signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.405761 Mm.466164 Mm.466230
RefSeq NM_010518
OMIM
CCDS CCDS15037
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca