Version 5.4
Mus musculus Gene: Naga
Summary
InnateDB Gene IDBG-166692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Naga
Gene Name N-acetyl galactosaminidase, alpha
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022453
Encoded Proteins
IDBP-166694
N-acetyl galactosaminidase, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198951:
NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]
NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:82329532-82338826
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000023088 ENSMUSP00000023088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004557 alpha-galactosidase activity
GO:0008456 alpha-N-acetylgalactosaminidase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0016052 carbohydrate catabolic process
GO:0016139 glycoside catabolic process
GO:0019377 glycolipid catabolic process
GO:0046477 glycosylceramide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198951
View Gene Order
ENSBTAG00000009506
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00603
Glycosphingolipid biosynthesis pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00603
Glycosphingolipid biosynthesis pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9QWR8
TrEMBL
UniProt Splice Variant
Entrez Gene 17939
UniGene
RefSeq NM_008669 XM_006520561
OMIM
CCDS CCDS27686
HPRD
IMGT
MGI ID MGI:1261422
MGI Symbol Naga
EMBL AF079458 AJ223966 AK077116 AY079439 AY079440 BC021631
GenPept AAC28851 AAH21631 AAL87527 AAL87528 BAC36620 CAA11703
RNA Seq Atlas 17939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca