InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Idh3a

Summary

InnateDB Gene

IDBG-166765.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Idh3a

Gene Name

isocitrate dehydrogenase 3 (NAD+) alpha

Synonyms

1110003P10Rik; 1500012E04Rik; AA407078; AI316514

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032279

Encoded Proteins

IDBP-624764

isocitrate dehydrogenase 3 (NAD+) alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166411:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:54586511-54604661

Strand

Forward strand

Band

A5.3

Transcripts

ENSMUST00000167866

ENSMUSP00000127526

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004449	isocitrate dehydrogenase (NAD+) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000166411

View Gene Order

ENSBTAG00000006227

Not yet available

Pathways

NETPATH

REACTOME

REACT_189162

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_188937

Metabolism pathway

REACT_241308

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_249033

Citric acid cycle (TCA cycle) pathway

KEGG

mmu00020

Citrate cycle (TCA cycle) pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1785

Citric acid cycle (TCA cycle) pathway

REACT_1046

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa00020

Citrate cycle (TCA cycle) pathway

INOH

INOH website

Citrate cycle pathway

PID NCI

Cross-References

SwissProt

Q9D6R2

TrEMBL

UniProt Splice Variant

Entrez Gene

67834

UniGene

RefSeq

NM_029573

OMIM

CCDS

CCDS23191

HPRD

IMGT

MGI ID

MGI:1915084

MGI Symbol

Idh3a

EMBL

AK003393 AK010065 AK032787 AK047951 AK150618 AK151304 AK152353 AK153459 AK158646 AK159051 AK168049 AK168149 AK169152 BC034273 BC049956

GenPept

AAH34273 AAH49956 BAB22760 BAB26679 BAC28021 BAC33199 BAE29708 BAE30286 BAE31145 BAE32011 BAE34596 BAE34785 BAE40031 BAE40114 BAE40931

RNA Seq Atlas

67834