Version 5.4
Mus musculus Gene: N4bp2
Summary
InnateDB Gene IDBG-166939.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol N4bp2
Gene Name NEDD4 binding protein 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037795
Encoded Proteins
IDBP-166943
NEDD4 binding protein 2
IDBP-253239
NEDD4 binding protein 2
IDBP-535148
NEDD4 binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078177:
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:65763521-65830108
Strand Forward strand
Band C3.1
Transcripts
ENSMUST00000087264 ENSMUSP00000084519
ENSMUST00000113738 ENSMUSP00000109367
ENSMUST00000137190
ENSMUST00000138607
ENSMUST00000138239 ENSMUSP00000119188
ENSMUST00000127411
ENSMUST00000136674
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0016310 phosphorylation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078177
View Gene Order
ENSBTAG00000000175
Not yet available
Cross-References
SwissProt
TrEMBL E9Q9B2 F8VQG7 Q8BX85
UniProt Splice Variant
Entrez Gene 333789
UniGene Mm.332398 Mm.370366 Mm.393231 Mm.487934
RefSeq NM_001024917 XM_006504003 XM_006504004 XM_006504005 XM_006504006 XM_006504007 XM_006504008 XM_006504009
OMIM
CCDS CCDS19310
HPRD
IMGT
MGI ID MGI:2684414
MGI Symbol N4bp2
EMBL AC156029 AK048616
GenPept BAC33393
RNA Seq Atlas 333789

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca