Version 5.4
Mus musculus Gene: Pgk1
Summary
InnateDB Gene IDBG-166967.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pgk1
Gene Name phosphoglycerate kinase 1
Synonyms Pgk-1
Species Mus musculus
Ensembl Gene ENSMUSG00000062070
Encoded Proteins
IDBP-166969
phosphoglycerate kinase 1
IDBP-787646
phosphoglycerate kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome X:106187100-106203699
Strand Forward strand
Band D
Transcripts
ENSMUST00000081593 ENSMUSP00000080302
ENSMUST00000135949 ENSMUSP00000138706
ENSMUST00000133559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004618 phosphoglycerate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102144
View Gene Order
ENSBTAG00000000894
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_232322
Glycolysis pathway
REACT_261601
Glucose metabolism pathway
REACT_188937
Metabolism pathway
REACT_263230
Gluconeogenesis pathway
REACT_203949
Glycogen storage diseases pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00010
Glycolysis / Gluconeogenesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_1520
Gluconeogenesis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_227222
Gluconeogenesis pathway
REACT_211129
Glycogen storage diseases pathway
REACT_224672
Glucose metabolism pathway
REACT_219139
Metabolism pathway
REACT_224187
Glycolysis pathway
REACT_207087
Disease pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL B0LAA9 S4R2M7
UniProt Splice Variant
Entrez Gene 18655
UniGene
RefSeq NM_008828
OMIM
CCDS CCDS30339
HPRD
IMGT
MGI ID MGI:97555
MGI Symbol Pgk1
EMBL BX469914 EF437325
GenPept ABS83503
RNA Seq Atlas 18655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca