Version 5.4
Mus musculus Gene: Wdr61
Summary
InnateDB Gene IDBG-167012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr61
Gene Name WD repeat domain 61
Synonyms 2700038L12Rik; 2810418I05Rik; REC14
Species Mus musculus
Ensembl Gene ENSMUSG00000061559
Encoded Proteins
IDBP-167014
WD repeat domain 61
IDBP-401048
WD repeat domain 61
IDBP-401046
WD repeat domain 61
IDBP-531901
WD repeat domain 61
IDBP-541083
WD repeat domain 61
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140395:
WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:54714735-54734519
Strand Reverse strand
Band A5.3
Transcripts
ENSMUST00000051822 ENSMUSP00000056359
ENSMUST00000118771 ENSMUSP00000112811
ENSMUST00000121204 ENSMUSP00000113560
ENSMUST00000130368 ENSMUSP00000123077
ENSMUST00000144365
ENSMUST00000148494
ENSMUST00000127451 ENSMUSP00000119362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016055 Wnt signaling pathway
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation
GO:2001162 positive regulation of histone H3-K79 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016593 Cdc73/Paf1 complex
GO:0035327 transcriptionally active chromatin
GO:0055087 Ski complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140395
View Gene Order
ENSBTAG00000015944
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28437
RefSeq NM_001025375 NM_001025376 NM_023191
OMIM
CCDS CCDS23194 CCDS59747
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca