Version 5.4
Mus musculus Gene: Exoc3
Summary
InnateDB Gene IDBG-167158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Exoc3
Gene Name exocyst complex component 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034152
Encoded Proteins
IDBP-167160
exocyst complex component 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180104:
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:74169805-74208700
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000035934 ENSMUSP00000039416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006887 exocytosis
GO:0008150 biological_process
GO:0015031 protein transport
Cellular Component
GO:0000145 exocyst
GO:0005575 cellular_component
GO:0030667 secretory granule membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000180104
View Gene Order
ENSBTAG00000008606
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_207837
Insulin processing pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_11123
Membrane Trafficking pathway
REACT_210701
Peptide hormone metabolism pathway
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_213782
Metabolism of proteins pathway
REACT_213260
Membrane Trafficking pathway
REACT_218634
Insulin processing pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
arf6_traffickingpathway
Arf6 trafficking events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt Q6KAR6
TrEMBL Q8K0E2 Q9ET46
UniProt Splice Variant
Entrez Gene 211446
UniGene Mm.489612
RefSeq NM_177333 XM_006517191
OMIM
CCDS CCDS26640
HPRD
IMGT
MGI ID MGI:2443972
MGI Symbol Exoc3
EMBL AF241783 AK131141 AK141537 BC031743 CH466563
GenPept AAG02037 AAH31743 BAD21391 BAE24723 EDL37087
RNA Seq Atlas 211446

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca