Version 5.4
Mus musculus Gene: Pram1
Summary
InnateDB Gene IDBG-167526.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pram1
Gene Name PML-RAR alpha-regulated adaptor molecule 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032739
Encoded Proteins
IDBP-167528
PML-RAR alpha-regulated adaptor molecule 1
IDBP-273677
PML-RAR alpha-regulated adaptor molecule 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133246:
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:33638056-33645706
Strand Forward strand
Band B1
Transcripts
ENSMUST00000052079 ENSMUSP00000057065
ENSMUST00000116619 ENSMUSP00000112318
ENSMUST00000166215
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0007229 integrin-mediated signaling pathway
GO:0043313 regulation of neutrophil degranulation
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133246
View Gene Order
ENSBTAG00000021041
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6BCL1
TrEMBL E9PYJ5
UniProt Splice Variant
Entrez Gene 378460
UniGene Mm.272606
RefSeq NM_001002842
OMIM
CCDS CCDS37569
HPRD
IMGT
MGI ID MGI:3576625
MGI Symbol Pram1
EMBL AY665714 CT033847
GenPept AAT76049
RNA Seq Atlas 378460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca