Version 5.4
Mus musculus Gene: Tbx22
Summary
InnateDB Gene IDBG-167649.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbx22
Gene Name T-box 22
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031241
Encoded Proteins
IDBP-167655
T-box 22
IDBP-400566
T-box 22
IDBP-622390
T-box 22
IDBP-622395
T-box 22
IDBP-622402
T-box 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122145:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:107667964-107688978
Strand Forward strand
Band D
Transcripts
ENSMUST00000068451 ENSMUSP00000063611
ENSMUST00000118986 ENSMUSP00000112544
ENSMUST00000172682 ENSMUSP00000133607
ENSMUST00000168174 ENSMUSP00000128247
ENSMUST00000168403 ENSMUSP00000127321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122145
View Gene Order
ENSBTAG00000048060
Not yet available
Cross-References
SwissProt Q8K402
TrEMBL
UniProt Splice Variant
Entrez Gene 245572
UniGene Mm.137011
RefSeq NM_145224 XM_006528036 NM_001290747 NM_181319 XM_006528040 XM_006528042 XM_006528044
OMIM
CCDS CCDS30350 CCDS30351 CCDS72420
HPRD
IMGT
MGI ID MGI:2389465
MGI Symbol Tbx22
EMBL AF516208 AY125891
GenPept AAM64167 AAM94354
RNA Seq Atlas 245572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca