InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Loxl4

Summary

InnateDB Gene

IDBG-167670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Loxl4

Gene Name

lysyl oxidase-like 4

Synonyms

4833426I20Rik; Loxc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025185

Encoded Proteins

IDBP-167672

lysyl oxidase-like 4

IDBP-621606

lysyl oxidase-like 4

IDBP-621607

lysyl oxidase-like 4

IDBP-621610

lysyl oxidase-like 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138131:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:42593982-42612813

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026190	ENSMUSP00000026190
ENSMUST00000164786	ENSMUSP00000125803
ENSMUST00000164014
ENSMUST00000166128	ENSMUSP00000126552
ENSMUST00000171432	ENSMUSP00000126686

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004720	protein-lysine 6-oxidase activity
GO:0005044	scavenger receptor activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0016020	membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000138131

View Gene Order

ENSBTAG00000020895

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_150206

Crosslinking of collagen fibrils pathway

REACT_150180

Assembly of collagen fibrils and other multimeric structures pathway

REACT_150366

Elastic fibre formation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_120729

Collagen formation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.178767

RefSeq

NM_001164311 NM_053083 XM_006527297 XM_006527298

OMIM

CCDS

CCDS29830 CCDS50441

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas