Mus musculus Gene: Txnrd3
Summary
InnateDB Gene IDBG-168003.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Txnrd3
Gene Name thioredoxin reductase 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000000811
Encoded Proteins
thioredoxin reductase 3
thioredoxin reductase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197763:
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:89643988-89675529
Strand Forward strand
Band D1
Transcripts
ENSMUST00000101171 ENSMUSP00000098730
ENSMUST00000000828 ENSMUSP00000000828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004791 thioredoxin-disulfide reductase activity
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Pyrimidine metabolism pathway
Selenocompound metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Pyrimidine metabolism pathway
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q99MD6
TrEMBL
UniProt Splice Variant
Entrez Gene 232223
UniGene Mm.229332
RefSeq NM_001178058 NM_001178059 NM_001178060 NM_153162
OMIM
CCDS CCDS57436 CCDS57437
HPRD
IMGT
MGI ID MGI:2386711
MGI Symbol Txnrd3
EMBL AF349659 AK012699 AK080362 BC076605
GenPept AAH76605 AAK31172 BAB28419 BAC37890
RNA Seq Atlas 232223