InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: S100a8

Summary

InnateDB Gene

IDBG-168077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100a8

Gene Name

S100 calcium binding protein A8 (calgranulin A)

Synonyms

60B8Ag; AI323541; B8Ag; Caga; CFAg; CP-10; MRP8; p8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056054

Encoded Proteins

IDBP-168079

S100 calcium binding protein A8 (calgranulin A)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21239714

S100a8 forms a complex with S100a9 and the complex is the site of interplay between extracellular Ca(2+) entry and intra-phagosomal reactive oxygen species production. S100A8 :: S100A9 acts as Ca(2+) sensor in phagosomal ROS production.

PMID 22423963

S100a8 is strongly upregulated in neutrophils upon bacterial infection, and sequesters zinc as a mechanism of nutritional immunity. Salmonella typhimurium overcomes this defence mechanism by expressing a high affinity zinc transporter.

PMID 23133376

S100A8 forms a heterodimer with S100A9 and is a key player in protective innate immunity during Klebsiella pneumonia infection.

PMID 25911757

S100a8/S100a9 are proinflammatory proteins that activate natural killer cells via Ager signalling.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:90669071-90670034

Strand

Forward strand

Band

Transcripts

ENSMUST00000069927

ENSMUSP00000064385

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0016209	antioxidant activity
GO:0035662	Toll-like receptor 4 binding
GO:0050544	arachidonic acid binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0002523	leukocyte migration involved in inflammatory response
GO:0002526	acute inflammatory response
GO:0002544	chronic inflammatory response
GO:0006914	autophagy
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010043	response to zinc ion
GO:0030593	neutrophil chemotaxis
GO:0032496	response to lipopolysaccharide
GO:0042060	wound healing
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0050729	positive regulation of inflammatory response
GO:0070488	neutrophil aggregation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_013650

OMIM

CCDS

CCDS38507

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas