Version 5.4
Mus musculus Gene: Pacsin2
Summary
InnateDB Gene IDBG-168133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pacsin2
Gene Name protein kinase C and casein kinase substrate in neurons 2
Synonyms AI197433
Species Mus musculus
Ensembl Gene ENSMUSG00000016664
Encoded Proteins
IDBP-168135
protein kinase C and casein kinase substrate in neurons 2
IDBP-623369
protein kinase C and casein kinase substrate in neurons 2
IDBP-623370
protein kinase C and casein kinase substrate in neurons 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100266:
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:83375607-83464606
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000056177 ENSMUSP00000058320
ENSMUST00000171436 ENSMUSP00000131504
ENSMUST00000165095 ENSMUSP00000130098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
GO:0070300 phosphatidic acid binding
Biological Process
GO:0007165 signal transduction
GO:0030036 actin cytoskeleton organization
GO:0036010 protein localization to endosome
GO:0045806 negative regulation of endocytosis
GO:0048858 cell projection morphogenesis
GO:0070836 caveola assembly
GO:0072584 caveolin-mediated endocytosis
GO:0097320 membrane tubulation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005901 caveola
GO:0005911 cell-cell junction
GO:0019898 extrinsic component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0032587 ruffle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100266
View Gene Order
ENSBTAG00000019290
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9WVE8
TrEMBL Q3TDA7 Q3UP40 Q8BNK9
UniProt Splice Variant
Entrez Gene 23970
UniGene Mm.23978
RefSeq NM_001159509 XM_006520979 XM_006520981 XM_006520982 XM_006520983 NM_001159510 NM_011862 XM_006520980
OMIM
CCDS CCDS27701
HPRD
IMGT
MGI ID MGI:1345153
MGI Symbol Pacsin2
EMBL AF128535 AK083414 AK143828 AK154785 AK170299 BC023502 CH466550
GenPept AAD41780 AAH23502 BAC38907 BAE25557 BAE32828 BAE41697 EDL04473 EDL04474
RNA Seq Atlas 23970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca