Version 5.4
Mus musculus Gene: Pou3f4
Summary
InnateDB Gene IDBG-168218.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pou3f4
Gene Name POU domain, class 3, transcription factor 4
Synonyms Brn-4; Brn4; oct-9; OTF-9; Otf9; Slf
Species Mus musculus
Ensembl Gene ENSMUSG00000056854
Encoded Proteins
IDBP-168220
POU domain, class 3, transcription factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196767:
This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:110814280-110817207
Strand Forward strand
Band E1
Transcripts
ENSMUST00000078229 ENSMUSP00000077354
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003680 AT DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007605 sensory perception of sound
GO:0021879 forebrain neuron differentiation
GO:0048839 inner ear development
GO:0090103 cochlea morphogenesis
GO:2001054 negative regulation of mesenchymal cell apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196767
View Gene Order
ENSBTAG00000015712
Not yet available
Cross-References
SwissProt P62515
TrEMBL A6H6L6 Q3TYV9
UniProt Splice Variant
Entrez Gene 18994
UniGene
RefSeq NM_008901
OMIM
CCDS CCDS30355
HPRD
IMGT
MGI ID MGI:101894
MGI Symbol Pou3f4
EMBL AK158302 BC138657 BC145919 CH466564 M88301
GenPept AAA39962 AAI38658 AAI45920 BAE34453 EDL14021
RNA Seq Atlas 18994

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca