Version 5.4
Mus musculus Gene: Uroc1
Summary
InnateDB Gene IDBG-168477.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uroc1
Gene Name urocanase domain containing 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034456
Encoded Proteins
IDBP-168479
urocanase domain containing 1
IDBP-621410
urocanase domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159650:
This gene encodes an enzyme involved in histidine catabolism, metabolizing urocanic acid to formiminoglutamic acid. The gene product is known to protect the skin from ultra violet rays and is contained in human sweat. Deficiency of this gene product in the liver is an apparent cause of mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:90333289-90364551
Strand Forward strand
Band D1
Transcripts
ENSMUST00000046128 ENSMUSP00000040424
ENSMUST00000164761 ENSMUSP00000127114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016153 urocanate hydratase activity
Biological Process
GO:0006548 histidine catabolic process
GO:0008152 metabolic process
GO:0019556 histidine catabolic process to glutamate and formamide
GO:0019557 histidine catabolic process to glutamate and formate
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159650
View Gene Order
ENSBTAG00000008774
Not yet available
Pathways
NETPATH
REACTOME
REACT_236760
Histidine catabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
KEGG
mmu00340
Histidine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1249
Histidine catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00340
Histidine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.335669 Mm.418573
RefSeq NM_144940 XM_006506091 XM_006506092 XM_006506093
OMIM
CCDS CCDS39561
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca