Version 5.4
Mus musculus Gene: Hcst
Summary
InnateDB Gene IDBG-168829.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hcst
Gene Name hematopoietic cell signal transducer
Synonyms DAP10; KAP10
Species Mus musculus
Ensembl Gene ENSMUSG00000064109
Encoded Proteins
IDBP-168831
hematopoietic cell signal transducer
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126264:
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30417717-30419854
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000075062 ENSMUSP00000074573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
Biological Process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Cellular Component
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126264
View Gene Order
ENSBTAG00000007336
Not yet available
Pathways
NETPATH
REACTOME
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_213138
Immune System pathway
REACT_214469
Adaptive Immune System pathway
REACT_215390
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011827
OMIM
CCDS CCDS39882
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca