InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bdkrb2

Summary

InnateDB Gene

IDBG-169186.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bdkrb2

Gene Name

bradykinin receptor, beta 2

Synonyms

B(2); B2; B2R; BK-2; BK2; BK2R; BKR2; BRB2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021070

Encoded Proteins

IDBP-169188

bradykinin receptor, beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18810490

[Homo sapiens] Involved in the early immune response against Listeria infection by increasing the production of IL12A/IL12B in human monocyte-derived dentritic cells

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168398:
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:105563172-105593071

Strand

Forward strand

Band

Transcripts

ENSMUST00000001652

ENSMUSP00000001652

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004930	G-protein coupled receptor activity
GO:0004947	bradykinin receptor activity
GO:0005515	protein binding
GO:0031702	type 1 angiotensin receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006939	smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0009651	response to salt stress
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042310	vasoconstriction
GO:0042311	vasodilation
GO:0050482	arachidonic acid secretion
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902239	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator