InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp46a1

Summary

InnateDB Gene

IDBG-170555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp46a1

Gene Name

cytochrome P450, family 46, subfamily a, polypeptide 1

Synonyms

Cyp46

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021259

Encoded Proteins

IDBP-170557

cytochrome P450, family 46, subfamily a, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000036530:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:108334377-108362231

Strand

Forward strand

Band

Transcripts

ENSMUST00000021684

ENSMUSP00000021684

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033781	cholesterol 24-hydroxylase activity