Version 5.4
| Mus musculus Gene: Btrc | |||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-170772.6 | ||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | Btrc | ||||||||||||||||||||||||||||||||||||||||
| Gene Name | beta-transducin repeat containing protein | ||||||||||||||||||||||||||||||||||||||||
| Synonyms | b-TrCP; beta-TrCP; Beta-Trcp1; E3RS-IkappaB; E3RSIkappaB; Fbw1a; FWD1; HOS; Slimb | ||||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000025217 | ||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
beta-transducin repeat containing protein
beta-transducin repeat containing protein
|
||||||||||||||||||||||||||||||||||||||||
| Protein Structure |
|
||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166167:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012] |
||||||||||||||||||||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 19:45363734-45533341 | ||||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||
| Band | C3 | ||||||||||||||||||||||||||||||||||||||||
| Transcripts |
|
||||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 150 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||||||||||||||||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||||||||||||||||||||
| Pathways | |||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||
| REACTOME |
Circadian Clock pathway
Nuclear signaling by ERBB4 pathway
G2/M Transition pathway
Mus musculus biological processes pathway
Signaling by the B Cell Receptor (BCR) pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Signaling by Wnt pathway
Circadian Clock pathway
Prolactin receptor signaling pathway
Hedgehog 'off' state pathway
Signaling by WNT in cancer pathway
Signaling by ERBB4 pathway
Degradation of beta-catenin by the destruction complex pathway
Cytokine Signaling in Immune system pathway
AMER1 mutants destabilize the destruction complex pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
deactivation of the beta-catenin transactivating complex pathway
APC truncation mutants have impaired AXIN binding pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Mitotic G2-G2/M phases pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Activation of NF-kappaB in B cells pathway
Degradation of GLI2 by the proteasome pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Regulation of mitotic cell cycle pathway
Degradation of GLI1 by the proteasome pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
GLI3 is processed to GLI3R by the proteasome pathway
Signaling by Interleukins pathway
APC truncation mutants are not K63 polyubiquitinated pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Regulation of PLK1 Activity at G2/M Transition pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
Adaptive Immune System pathway
truncations of AMER1 destabilize the destruction complex pathway
Signaling by Hedgehog pathway
Interleukin-1 signaling pathway
Signal Transduction pathway
truncated APC mutants destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
|
||||||||||||||||||||||||||||||||||||||||
| KEGG |
Ubiquitin mediated proteolysis pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Circadian rhythm pathway
Oocyte meiosis pathway
|
||||||||||||||||||||||||||||||||||||||||
| INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
|
||||||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||
| NETPATH |
TGF_beta_Receptor pathway
Wnt pathway
TNFalpha pathway
Prolactin pathway
|
||||||||||||||||||||||||||||||||||||||||
| REACTOME |
SCF-beta-TrCP mediated degradation of Emi1 pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Interleukin-1 signaling pathway
Prolactin receptor signaling pathway
Activation of NF-kappaB in B cells pathway
Nuclear signaling by ERBB4 pathway
Signaling by ERBB4 pathway
Degradation of beta-catenin by the destruction complex pathway
Circadian Clock pathway
Vpu mediated degradation of CD4 pathway
truncated APC mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
AXIN missense mutants destabilize the destruction complex pathway
Regulation of mitotic cell cycle pathway
Signaling by Wnt pathway
Cytokine Signaling in Immune system pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
deactivation of the beta-catenin transactivating complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Signaling by Interleukins pathway
G2/M Transition pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
Mitotic G2-G2/M phases pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
|
||||||||||||||||||||||||||||||||||||||||
| KEGG |
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Circadian rhythm pathway
Oocyte meiosis pathway
Shigellosis pathway
|
||||||||||||||||||||||||||||||||||||||||
| INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
|
||||||||||||||||||||||||||||||||||||||||
| PID NCI |
Atypical NF-kappaB pathway
Presenilin action in Notch and Wnt signaling
Signaling events mediated by HDAC Class I
Regulation of nuclear beta catenin signaling and target gene transcription
Canonical NF-kappaB pathway
Hedgehog signaling events mediated by Gli proteins
Degradation of beta catenin
Validated transcriptional targets of TAp63 isoforms
Alternative NF-kappaB pathway
Notch signaling pathway
|
||||||||||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||||||||||
| SwissProt | Q3ULA2 | ||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 12234 | ||||||||||||||||||||||||||||||||||||||||
| UniGene | Mm.119717 | ||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001286466 NM_009771 XM_006526608 XM_006526609 XM_006526610 XM_006526611 XM_006526612 XM_006526613 XM_006526614 NM_001037758 NM_001286465 XM_006526607 XM_006526615 | ||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS38002 CCDS29860 | ||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||
| MGI ID | MGI:1338871 | ||||||||||||||||||||||||||||||||||||||||
| MGI Symbol | Btrc | ||||||||||||||||||||||||||||||||||||||||
| EMBL | AF081887 AF099932 AF110396 AF112979 AF391178 AF391179 AF391180 AF391181 AF391182 AF391183 AF391184 AF391185 AF391186 AF391187 AF391188 AF391189 AF391190 AK145624 AK156660 AK220183 BC003989 CH466534 | ||||||||||||||||||||||||||||||||||||||||
| GenPept | AAD04181 AAD08701 AAD17755 AAD41025 AAH03989 AAL40929 BAD90368 BAE26547 BAE33798 EDL41951 | ||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 12234 | ||||||||||||||||||||||||||||||||||||||||