Version 5.4
Mus musculus Gene: Inpp4b
Summary
InnateDB Gene IDBG-171342.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Inpp4b
Gene Name inositol polyphosphate-4-phosphatase, type II
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037940
Encoded Proteins
IDBP-171344
inositol polyphosphate-4-phosphatase, type II
IDBP-261506
inositol polyphosphate-4-phosphatase, type II
IDBP-261508
inositol polyphosphate-4-phosphatase, type II
IDBP-620833
inositol polyphosphate-4-phosphatase, type II
IDBP-620844
inositol polyphosphate-4-phosphatase, type II
IDBP-620850
inositol polyphosphate-4-phosphatase, type II
IDBP-620852
inositol polyphosphate-4-phosphatase, type II
IDBP-620855
inositol polyphosphate-4-phosphatase, type II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109452:
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:81342556-82125036
Strand Forward strand
Band C2
Transcripts
ENSMUST00000042529 ENSMUSP00000044466
ENSMUST00000109852 ENSMUSP00000105478
ENSMUST00000109851 ENSMUSP00000105477
ENSMUST00000172167 ENSMUSP00000131598
ENSMUST00000169116 ENSMUSP00000131947
ENSMUST00000169387 ENSMUSP00000130104
ENSMUST00000172031 ENSMUSP00000131324
ENSMUST00000164870
ENSMUST00000171076
ENSMUST00000170160 ENSMUSP00000132156
ENSMUST00000164264
ENSMUST00000165821
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034593 phosphatidylinositol bisphosphate phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0016311 dephosphorylation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0045671 negative regulation of osteoclast differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046850 regulation of bone remodeling
GO:0051896 regulation of protein kinase B signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109452
View Gene Order
ENSBTAG00000014111
Not yet available
Pathways
NETPATH
REACTOME
REACT_196478
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_198975
Synthesis of PIPs at the early endosome membrane pathway
REACT_198973
Synthesis of PIPs at the plasma membrane pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188643
Phospholipid metabolism pathway
REACT_196476
Inositol phosphate metabolism pathway
KEGG
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.324468 Mm.464002
RefSeq NM_001024617 XM_006530854 XM_006530855 XM_006530856 XM_006530857 XM_006530858 XM_006530859 XM_006530862 XM_006530863
OMIM
CCDS CCDS22446
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca