Version 5.4
Homo sapiens Gene: CILP
Summary
InnateDB Gene IDBG-17139.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CILP
Gene Name cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Synonyms CILP-1; HsT18872
Species Homo sapiens
Ensembl Gene ENSG00000138615
Encoded Proteins
IDBP-17141
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:65194758-65211488
Strand Reverse strand
Band q22.31
Transcripts
ENST00000261883 ENSP00000261883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042254
View Gene Order
ENSBTAG00000002821
Not yet available
Cross-References
SwissProt O75339
TrEMBL
UniProt Splice Variant
Entrez Gene 8483
UniGene Hs.442180
RefSeq NM_003613
HUGO HGNC:1980
OMIM 603489
CCDS CCDS10203
HPRD
IMGT
EMBL AB022430 AC068213 AF035408 AF035448 AF035449 AF035451 AF035453 AF035455 AK313352 AY358904 BC035776
GenPept AAC33838 AAF14689 AAH35776 AAQ89263 BAA76692 BAG36154
RNA Seq Atlas 8483

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca