Version 5.4
| Mus musculus Gene: Tnfaip8l2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-171590.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Tnfaip8l2 | ||||||||||||||||||
| Gene Name | tumor necrosis factor, alpha-induced protein 8-like 2 | ||||||||||||||||||
| Synonyms | 1810019A08Rik; AW610835; TIPE2 | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000013707 | ||||||||||||||||||
| Encoded Proteins |
tumor necrosis factor, alpha-induced protein 8-like 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
Tnfaip8l2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway.
Tnfaip8l2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Homo sapiens] TNFAIP8L2 is a negative regulator of innate and adaptive immunity that maintains immune homeostasis by binding to CASP8 and inhibiting nuclear factor kappa B activation while promoting apoptosis.
[Homo sapiens] TNFAIP8L2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway. (Demonstrated in mouse)
[Homo sapiens] TNFAIP8L2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection. (Demonstrated in mice)
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163154:
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 3:95139521-95142360 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | F2.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | Q9D8Y7 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 69769 | ||||||||||||||||||
| UniGene | Mm.34368 | ||||||||||||||||||
| RefSeq | NM_027206 XM_006502040 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS17603 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:1917019 | ||||||||||||||||||
| MGI Symbol | Tnfaip8l2 | ||||||||||||||||||
| EMBL | AF548004 AK007540 BC055879 BC094616 | ||||||||||||||||||
| GenPept | AAH55879 AAH94616 AAQ12263 BAB25098 | ||||||||||||||||||
| RNA Seq Atlas | 69769 | ||||||||||||||||||