InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim13

Summary

InnateDB Gene

IDBG-171622.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim13

Gene Name

tripartite motif-containing 13

Synonyms

3110001L12Rik; CAR; LEU5; Rfp2; RNF77

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035235

Encoded Proteins

IDBP-171624

tripartite motif-containing 13

IDBP-620378

tripartite motif-containing 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM13 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204977:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:61598226-61605946

Strand

Forward strand

Band

Transcripts

ENSMUST00000039562	ENSMUSP00000045009
ENSMUST00000165015	ENSMUSP00000128509

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0010332	response to gamma radiation
GO:0010942	positive regulation of cell death
GO:0016239	positive regulation of macroautophagy
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0032897	negative regulation of viral transcription
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0097038	perinuclear endoplasmic reticulum

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000204977

View Gene Order

ENSBTAG00000008173

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.23959 Mm.405992 Mm.490061

RefSeq

NM_001164220 NM_023233 XM_006519392

OMIM

CCDS

CCDS27186

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas