InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Epha4

Summary

InnateDB Gene

IDBG-172040.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha4

Gene Name

Eph receptor A4

Synonyms

2900005C20Rik; AI385584; Cek8; Hek8; rb; Sek; Sek1; Tyro1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026235

Encoded Proteins

IDBP-172042

Eph receptor A4

IDBP-789512

Eph receptor A4

IDBP-789513

Eph receptor A4

IDBP-789514

Eph receptor A4

IDBP-789516

Eph receptor A4

IDBP-789517

Eph receptor A4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116106:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:77367185-77515088

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027451	ENSMUSP00000027451
ENSMUST00000188952	ENSMUSP00000139640
ENSMUST00000188797	ENSMUSP00000140954
ENSMUST00000187346	ENSMUSP00000140631
ENSMUST00000190149	ENSMUSP00000140408
ENSMUST00000189934
ENSMUST00000186930	ENSMUSP00000140370

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	18 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042731	PH domain binding
GO:0042802	identical protein binding
GO:0046875	ephrin receptor binding
GO:0097161	DH domain binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0007628	adult walking behavior
GO:0008045	motor neuron axon guidance
GO:0008347	glial cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021957	corticospinal tract morphogenesis
GO:0032314	regulation of Rac GTPase activity
GO:0032317	regulation of Rap GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0043507	positive regulation of JUN kinase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048681	negative regulation of axon regeneration
GO:0048710	regulation of astrocyte differentiation
GO:0050770	regulation of axonogenesis
GO:0050775	positive regulation of dendrite morphogenesis
GO:0061001	regulation of dendritic spine morphogenesis
GO:0097155	fasciculation of sensory neuron axon
GO:0097156	fasciculation of motor neuron axon
GO:2001108	positive regulation of Rho guanyl-nucleotide exchange factor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030424	axon
GO:0030425	dendrite
GO:0031594	neuromuscular junction
GO:0031901	early endosome membrane
GO:0042995	cell projection
GO:0043197	dendritic spine
GO:0043204	perikaryon
GO:0043679	axon terminus
GO:0044295	axonal growth cone
GO:0044297	cell body
GO:0045211	postsynaptic membrane