Version 5.4
Mus musculus Gene: Fxyd7
Summary
InnateDB Gene IDBG-172052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fxyd7
Gene Name FXYD domain-containing ion transport regulator 7
Synonyms 1110035I01Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000036578
Encoded Proteins
IDBP-172054
FXYD domain-containing ion transport regulator 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:31042517-31051462
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000073892 ENSMUSP00000073555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0051117 ATPase binding
Biological Process
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0043269 regulation of ion transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_250224
Ion transport by P-type ATPases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P59648
TrEMBL
UniProt Splice Variant
Entrez Gene 57780
UniGene
RefSeq NM_022007
OMIM
CCDS CCDS21122
HPRD
IMGT
MGI ID MGI:1889006
MGI Symbol Fxyd7
EMBL AK004113
GenPept BAC25067
RNA Seq Atlas 57780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca