InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rcor1

Summary

InnateDB Gene

IDBG-172449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rcor1

Gene Name

REST corepressor 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037896

Encoded Proteins

IDBP-172451

REST corepressor 1

IDBP-274247

REST corepressor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20798038

[Homo sapiens] Co-repressor of REST (RCOR1) is part of a repressor complex, along with key components that include histone deacetylase 1 or 2, RE-1 silencing transcription factor (REST), and lysine-specific demethylase (LSD) 1. The HDAC/RCOR1/REST/LSD1 repressor complex is a significant component of host innate immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089902:
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:111039351-111115901

Strand

Forward strand

Band

Transcripts

ENSMUST00000084968	ENSMUSP00000082034
ENSMUST00000116388	ENSMUSP00000112089

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030218	erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070933	histone H4 deacetylation