InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mapk11

Summary

InnateDB Gene

IDBG-172712.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapk11

Gene Name

mitogen-activated protein kinase 11

Synonyms

p38-2; P38b; p38beta; p38beta2; Prkm11; Sapk2; Sapk2b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053137

Encoded Proteins

IDBP-172714

mitogen-activated protein kinase 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185386:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:89142486-89149606

Strand

Reverse strand

Band

Transcripts

ENSMUST00000088823

ENSMUSP00000086204

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0009103	lipopolysaccharide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000185386

View Gene Order

ENSBTAG00000030182

Not yet available

Pathways

NETPATH

REACTOME

REACT_263316

Toll Like Receptor 3 (TLR3) Cascade pathway

REACT_229712

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway

REACT_263004

Toll Like Receptor 2 (TLR2) Cascade pathway

REACT_239142

Innate Immune System pathway

REACT_188970

Oxidative Stress Induced Senescence pathway

REACT_224594

Organelle biogenesis and maintenance pathway

REACT_204811

Activation of the AP-1 family of transcription factors pathway

REACT_210065

MAPK targets/ Nuclear events mediated by MAP kinases pathway

REACT_198687

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_188957

Cellular responses to stress pathway

REACT_245896

MyD88 cascade initiated on plasma membrane pathway

REACT_227951

Signaling by VEGF pathway

REACT_215063

ERK/MAPK targets pathway

REACT_198696

KSRP destabilizes mRNA pathway

REACT_255939

Toll Like Receptor TLR1:TLR2 Cascade pathway

REACT_262171

MAP kinase activation in TLR cascade pathway

REACT_230745

Immune System pathway

REACT_253473

Myogenesis pathway

REACT_260773

Toll Like Receptor 5 (TLR5) Cascade pathway

REACT_254406

Toll Like Receptor TLR6:TLR2 Cascade pathway

REACT_237946

activated TAK1 mediates p38 MAPK activation pathway

REACT_243212

DSCAM interactions pathway

REACT_188820

Cellular Senescence pathway

REACT_239722

Signalling to RAS pathway

REACT_249409

Toll Like Receptor 9 (TLR9) Cascade pathway

REACT_258600

CDO in myogenesis pathway

REACT_207601

p38MAPK events pathway

REACT_257088

VEGFA-VEGFR2 Pathway pathway

REACT_251547

Toll-Like Receptors Cascades pathway

REACT_231290

Signalling to ERKs pathway

REACT_211125

NOD1/2 Signaling Pathway pathway

REACT_256727

MyD88 dependent cascade initiated on endosome pathway

REACT_248921

Signalling by NGF pathway

REACT_233572

Gene Expression pathway

REACT_188576

Developmental Biology pathway

REACT_206758

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway

REACT_262462

Activated TLR4 signalling pathway

REACT_237883

NGF signalling via TRKA from the plasma membrane pathway

REACT_241786

MyD88-independent cascade pathway

REACT_188257

Signal Transduction pathway

REACT_211261

Mitochondrial biogenesis pathway

REACT_242921

Toll Like Receptor 7/8 (TLR7/8) Cascade pathway

REACT_230045

MyD88:Mal cascade initiated on plasma membrane pathway

REACT_238546

TRIF-mediated TLR3/TLR4 signaling pathway

REACT_223082

Cell-Cell communication pathway

REACT_205688

Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway

REACT_222431

Nuclear Events (kinase and transcription factor activation) pathway

REACT_261340

Toll Like Receptor 10 (TLR10) Cascade pathway

REACT_246719

Toll Like Receptor 4 (TLR4) Cascade pathway

KEGG

mmu04370

VEGF signaling pathway pathway

mmu04660

T cell receptor signaling pathway pathway

mmu04620

Toll-like receptor signaling pathway pathway

mmu04664

Fc epsilon RI signaling pathway pathway

mmu04912

GnRH signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

mmu04670

Leukocyte transendothelial migration pathway

mmu05014

Amyotrophic lateral sclerosis (ALS) pathway

mmu04722

Neurotrophin signaling pathway pathway

mmu04914

Progesterone-mediated oocyte maturation pathway

mmu04622

RIG-I-like receptor signaling pathway pathway

mmu04621

NOD-like receptor signaling pathway pathway

mmu05140

Leishmaniasis pathway

mmu04380

Osteoclast differentiation pathway

mmu05145

Toxoplasmosis pathway

mmu05160

Hepatitis C pathway

mmu05142

Chagas disease (American trypanosomiasis) pathway

INOH