Version 5.4
Mus musculus Gene: Stk11
Summary
InnateDB Gene IDBG-172765.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stk11
Gene Name serine/threonine kinase 11
Synonyms AA408040; Lkb1; Par-4; R75140
Species Mus musculus
Ensembl Gene ENSMUSG00000003068
Encoded Proteins
IDBP-172767
serine/threonine kinase 11
IDBP-271019
serine/threonine kinase 11
IDBP-271021
serine/threonine kinase 11
IDBP-539944
serine/threonine kinase 11
IDBP-531639
serine/threonine kinase 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80115803-80130682
Strand Forward strand
Band C1
Transcripts
ENSMUST00000003152 ENSMUSP00000003152
ENSMUST00000105371 ENSMUSP00000101010
ENSMUST00000105370 ENSMUSP00000101009
ENSMUST00000144883 ENSMUSP00000114195
ENSMUST00000128992
ENSMUST00000144119
ENSMUST00000129235
ENSMUST00000144108
ENSMUST00000152592 ENSMUSP00000118853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030275 LRR domain binding
GO:0030295 protein kinase activator activity
GO:0032403 protein complex binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001894 tissue homeostasis
GO:0001944 vasculature development
GO:0006468 protein phosphorylation
GO:0006914 autophagy
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007286 spermatid development
GO:0007409 axonogenesis
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0010212 response to ionizing radiation
GO:0030010 establishment of cell polarity
GO:0030111 regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 activation of protein kinase activity
GO:0033762 response to glucagon
GO:0033993 response to lipid
GO:0036399 TCR signalosome assembly
GO:0042593 glucose homeostasis
GO:0043276 anoikis
GO:0043434 response to peptide hormone
GO:0045059 positive thymic T cell selection
GO:0045722 positive regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772 positive regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051291 protein heterooligomerization
GO:0051645 Golgi localization
GO:0051896 regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0036398 TCR signalosome
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118046
View Gene Order
ENSBTAG00000011639
Not yet available
Pathways
NETPATH
REACTOME
REACT_220701
Regulation of AMPK activity via LKB1 pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188937
Metabolism pathway
REACT_204167
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_240139
PI3K Cascade pathway
REACT_250379
AMPK inhibits chREBP transcriptional activation activity pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_188257
Signal Transduction pathway
REACT_255725
mTOR signalling pathway
REACT_256714
PKB-mediated events pathway
KEGG
mmu04150
mTOR signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_21285
Regulation of AMPK activity via LKB1 pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_1988
AMPK inhibits chREBP transcriptional activation activity pathway
REACT_1505
Integration of energy metabolism pathway
REACT_21387
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_456
PKB-mediated events pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_111217
Metabolism pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt Q9WTK7
TrEMBL B3VBP0
UniProt Splice Variant
Entrez Gene 20869
UniGene Mm.44231
RefSeq NM_011492 XM_006513440
OMIM
CCDS CCDS35974
HPRD
IMGT
MGI ID MGI:1341870
MGI Symbol Stk11
EMBL AB015801 AF129870 AF145287 AF145288 AF145289 AF145290 AF145291 AF145292 AF145293 AF145294 AF145295 AF145296 AF151711 AK171909 AK172385 AK172528 BC052379 EU730638
GenPept AAD22100 AAD31044 AAD55368 AAF21370 AAH52379 ACE73833 BAA76749 BAE42728 BAE42977 BAE43050
RNA Seq Atlas 20869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca