InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ctsk

Summary

InnateDB Gene

IDBG-172787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsk

Gene Name

cathepsin K

Synonyms

AI323530; catK; MMS10-Q; Ms10q

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028111

Encoded Proteins

IDBP-172789

cathepsin K

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18762176

[Homo sapiens] CTSK is a cathepsins, which are key modulators of cell death and inflammatory responses.

PMID 25884905

[Homo sapiens] Cleavage of CAMP by cathepsins CTSS and CTSK impairs its antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143387:
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:95499286-95509362

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000015664

ENSMUSP00000015664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005518	collagen binding
GO:0008234	cysteine-type peptidase activity
GO:0043394	proteoglycan binding

Biological Process

GO:0001957	intramembranous ossification
GO:0006508	proteolysis
GO:0030574	collagen catabolic process
GO:0045453	bone resorption
GO:0051603	proteolysis involved in cellular protein catabolic process