Version 5.4
Mus musculus Gene: Scg2
Summary
InnateDB Gene IDBG-172842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scg2
Gene Name secretogranin II
Synonyms Chgc; SgII
Species Mus musculus
Ensembl Gene ENSMUSG00000050711
Encoded Proteins
IDBP-172844
secretogranin II
IDBP-789228
secretogranin II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171951:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:79434669-79440120
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000049972 ENSMUSP00000062556
ENSMUST00000185234 ENSMUSP00000139740
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0042056 chemoattractant activity
Biological Process
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006928 cellular component movement
GO:0035556 intracellular signal transduction
GO:0048245 eosinophil chemotaxis
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171951
View Gene Order
ENSBTAG00000021588
Not yet available
Cross-References
SwissProt
TrEMBL Q4W8U9
UniProt Splice Variant
Entrez Gene 20254
UniGene
RefSeq XM_006496446 NM_009129
OMIM
CCDS CCDS15089
HPRD
IMGT
MGI ID MGI:103033
MGI Symbol Scg2
EMBL BC048249
GenPept AAH48249
RNA Seq Atlas 20254

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca