Version 5.4
Mus musculus Gene: Wdfy1
Summary
InnateDB Gene IDBG-172895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdfy1
Gene Name WD repeat and FYVE domain containing 1
Synonyms 1700013B03Rik; 1700120F24Rik; FENS-1; Jr1; mKIAA1435; WDF1; ZFYVE17
Species Mus musculus
Ensembl Gene ENSMUSG00000073643
Encoded Proteins
IDBP-172982
WD repeat and FYVE domain containing 1
IDBP-253716
WD repeat and FYVE domain containing 1
IDBP-253718
WD repeat and FYVE domain containing 1
IDBP-253720
WD repeat and FYVE domain containing 1
IDBP-253722
WD repeat and FYVE domain containing 1
IDBP-253724
WD repeat and FYVE domain containing 1
IDBP-253726
WD repeat and FYVE domain containing 1
IDBP-532428
WD repeat and FYVE domain containing 1
IDBP-534496
WD repeat and FYVE domain containing 1
IDBP-788565
WD repeat and FYVE domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25736436
Wdfy1 is a crucial adaptor protein in the Tlr3/4 signalling pathway. Wdfy1 interacts with Tlr3 and Tlr4 and mediates the recruitment of Ticam1 to these receptors.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085449:
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains a single FYVE domain and multiple WD40 repeats. This protein is localized to endosomes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:79702262-79776143
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000048820 ENSMUSP00000040224
ENSMUST00000113515 ENSMUSP00000109143
ENSMUST00000113514 ENSMUSP00000109142
ENSMUST00000113513 ENSMUSP00000109141
ENSMUST00000113512 ENSMUSP00000109140
ENSMUST00000113511 ENSMUSP00000109139
ENSMUST00000113510 ENSMUSP00000109138
ENSMUST00000127771
ENSMUST00000130714
ENSMUST00000143368 ENSMUSP00000123303
ENSMUST00000138319
ENSMUST00000125641 ENSMUSP00000118431
ENSMUST00000187005 ENSMUSP00000139961
ENSMUST00000186464
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005769 early endosome
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000085449
View Gene Order
ENSBTAG00000016951
Not yet available
Cross-References
SwissProt
TrEMBL D3YWG9 D3Z057
UniProt Splice Variant
Entrez Gene 69368
UniGene Mm.293273 Mm.471121 Mm.487044 Mm.489247
RefSeq NM_001111279 NM_027057 XM_006496543 XM_006496546
OMIM
CCDS CCDS15090 CCDS48296
HPRD
IMGT
MGI ID MGI:1916618
MGI Symbol Wdfy1
EMBL AC083910 AC170750
GenPept
RNA Seq Atlas 69368

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca