InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dazap1

Summary

InnateDB Gene

IDBG-173441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dazap1

Gene Name

DAZ associated protein 1

Synonyms

2410042M16Rik; mPrrp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000069565

Encoded Proteins

IDBP-173443

DAZ associated protein 1

IDBP-271037

DAZ associated protein 1

IDBP-271039

DAZ associated protein 1

IDBP-542871

DAZ associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071626:
In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80261486-80288408

Strand

Forward strand

Band

Transcripts

ENSMUST00000092305	ENSMUSP00000089958
ENSMUST00000105362	ENSMUSP00000101001
ENSMUST00000105361	ENSMUSP00000101000
ENSMUST00000156935	ENSMUSP00000117497
ENSMUST00000150328
ENSMUST00000138032
ENSMUST00000151619

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0035613	RNA stem-loop binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001893	maternal placenta development
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0030154	cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000071626

View Gene Order

ENSBTAG00000019714

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03015

mRNA surveillance pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03015

mRNA surveillance pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.148693 Mm.407287

RefSeq

NM_001122604 NM_001122605 NM_133188 XM_006514069 XM_006514070 XM_006514071 XM_006514072 XM_006514073

OMIM

CCDS

CCDS35977 CCDS48626 CCDS48627

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas