Version 5.4
| Mus musculus Gene: Il5ra | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-173890.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Il5ra | ||||||||
| Gene Name | interleukin 5 receptor, alpha | ||||||||
| Synonyms | CD125; CDw125; Il5r | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000005364 | ||||||||
| Encoded Proteins |
interleukin 5 receptor, alpha
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091181:
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 6:106711975-106745109 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | E1 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
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| INOH |
JAK STAT pathway and regulation pathway
IL-5 signaling pathway
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| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
IL5 pathway
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| REACTOME |
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
GPVI-mediated activation cascade pathway
G beta:gamma signalling through PI3Kgamma pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
Signaling by Interleukins pathway
Hemostasis pathway
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| KEGG |
Hematopoietic cell lineage pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
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| INOH |
JAK STAT pathway and regulation pathway
IL-5 signaling pathway
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| PID NCI |
IL5-mediated signaling events
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| Cross-References | |||||||||
| SwissProt | P21183 | ||||||||
| TrEMBL | Q05A81 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 16192 | ||||||||
| UniGene | Mm.3448 | ||||||||
| RefSeq | NM_008370 XM_006505619 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS20396 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:96558 | ||||||||
| MGI Symbol | Il5ra | ||||||||
| EMBL | BC125374 CH466523 D90205 | ||||||||
| GenPept | AAI25375 BAA14231 EDK99395 | ||||||||
| RNA Seq Atlas | 16192 | ||||||||