InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rest

Summary

InnateDB Gene

IDBG-173982.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rest

Gene Name

RE1-silencing transcription factor

Synonyms

2610008J04Rik; AA407358; NRSF

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029249

Encoded Proteins

IDBP-173984

RE1-silencing transcription factor

IDBP-253855

RE1-silencing transcription factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20798038

[Homo sapiens] RE-1 silencing transcription factor (REST) is part of a repressor complex, along with key components that include histone deacetylase (HDAC) 1 or 2, co-repressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. The HDAC/CoREST/REST/LSD1 repressor complex is a significant component of host innate immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084093:
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:77265491-77286432

Strand

Forward strand

Band

C3.3

Transcripts

ENSMUST00000080359	ENSMUSP00000079231
ENSMUST00000113449	ENSMUSP00000109076

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0015271	outward rectifier potassium channel activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010629	negative regulation of gene expression
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0035690	cellular response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922	negative regulation by host of viral transcription
GO:0045665	negative regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0046676	negative regulation of insulin secretion
GO:0050768	negative regulation of neurogenesis
GO:0060379	cardiac muscle cell myoblast differentiation
GO:0070933	histone H4 deacetylation
GO:0071257	cellular response to electrical stimulus
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071805	potassium ion transmembrane transport
GO:2000065	negative regulation of cortisol biosynthetic process
GO:2000706	negative regulation of dense core granule biogenesis
GO:2000740	negative regulation of mesenchymal stem cell differentiation
GO:2000798	negative regulation of amniotic stem cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0017053	transcriptional repressor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000084093

View Gene Order

ENSBTAG00000011789

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_202766

Chromatin modifying enzymes pathway

REACT_257106

HDACs deacetylate histones pathway

KEGG

mmu05016

Huntington's disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228222

HDACs deacetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

Q8VIG1

TrEMBL

UniProt Splice Variant

Entrez Gene

19712

UniGene

Mm.28840 Mm.393678 Mm.394825 Mm.471386 Mm.482359

RefSeq

NM_011263 XM_006534841 XM_006534842

OMIM

CCDS

CCDS19372

HPRD

IMGT

MGI ID

MGI:104897

MGI Symbol

Rest

EMBL

AB024496 AK004945 AK156514 BC096434 BC127065 DQ644039

GenPept

AAH96434 AAI27066 ABG35129 BAB23689 BAB82460 BAE33741

RNA Seq Atlas

19712