Version 5.4
Mus musculus Gene: Tle3
Summary
InnateDB Gene IDBG-174195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tle3
Gene Name transducin-like enhancer of split 3, homolog of Drosophila E(spl)
Synonyms 2610103N05Rik; ESG; Grg3a; Grg3b; mKIAA1547
Species Mus musculus
Ensembl Gene ENSMUSG00000032280
Encoded Proteins
IDBP-174197
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-533214
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-537798
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-539609
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-534308
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-541746
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-534736
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-532686
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-540170
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-541011
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-532560
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-535813
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-538026
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-532847
transducin-like enhancer of split 3, homolog of Drosophila E(spl)
IDBP-741785
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140332:
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:61372366-61418497
Strand Forward strand
Band B
Transcripts
ENSMUST00000034820 ENSMUSP00000034820
ENSMUST00000159386 ENSMUSP00000125049
ENSMUST00000162583 ENSMUSP00000124977
ENSMUST00000161993 ENSMUSP00000124432
ENSMUST00000160882 ENSMUSP00000124131
ENSMUST00000160724 ENSMUSP00000124055
ENSMUST00000162973 ENSMUSP00000124173
ENSMUST00000159050 ENSMUSP00000125032
ENSMUST00000160541 ENSMUSP00000124158
ENSMUST00000161207 ENSMUSP00000124557
ENSMUST00000159630 ENSMUSP00000123723
ENSMUST00000161689 ENSMUSP00000125011
ENSMUST00000161194 ENSMUSP00000125537
ENSMUST00000162127 ENSMUSP00000124150
ENSMUST00000162962
ENSMUST00000159140
ENSMUST00000162281
ENSMUST00000178113 ENSMUSP00000136010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0016055 Wnt signaling pathway
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140332
View Gene Order
ENSBTAG00000015580
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_258066
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_203336
Degradation of beta-catenin by the destruction complex pathway
REACT_233471
repression of WNT target genes pathway
REACT_235529
AMER1 mutants destabilize the destruction complex pathway
REACT_231507
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_258576
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_219771
deactivation of the beta-catenin transactivating complex pathway
REACT_216539
formation of the beta-catenin:TCF transactivating complex pathway
REACT_230286
APC truncation mutants have impaired AXIN binding pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_241514
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_236203
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_234076
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_252458
AXIN missense mutants destabilize the destruction complex pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_263691
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_248000
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_261276
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_254498
TCF7L2 mutants don't bind CTBP pathway
REACT_250714
truncations of AMER1 destabilize the destruction complex pathway
REACT_196464
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_188257
Signal Transduction pathway
REACT_237096
truncated APC mutants destabilize the destruction complex pathway
REACT_231152
Signaling by NOTCH pathway
REACT_260752
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24255 Mm.407394 Mm.453625 Mm.469199 Mm.482666
RefSeq NM_001083927 NM_001083928 NM_009389 XM_006511025 XM_006511026 XM_006511027 XM_006511028 XM_006511029 XM_006511030 XM_006511031 XM_006511032 XM_006511033
OMIM
CCDS CCDS52824 CCDS52825 CCDS52826
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca