InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCT6A

Summary

InnateDB Gene

IDBG-17442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCT6A

Gene Name

chaperonin containing TCP1, subunit 6A (zeta 1)

Synonyms

CCT-zeta; CCT-zeta-1; CCT6; Cctz; HTR3; MoDP-2; TCP-1-zeta; TCP20; TCPZ; TTCP20

Species

Homo sapiens

Ensembl Gene

ENSG00000146731

Encoded Proteins

IDBP-17444

chaperonin containing TCP1, subunit 6A (zeta 1)

IDBP-17446

chaperonin containing TCP1, subunit 6A (zeta 1)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:56051630-56063989

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000275603	ENSP00000275603
ENST00000335503	ENSP00000352019
ENST00000493855
ENST00000482776
ENST00000492618
ENST00000466572
ENST00000462133
ENST00000494736
ENST00000466479

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	94 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002199	zona pellucida receptor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome