InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bhlhe40

Summary

InnateDB Gene

IDBG-174608.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bhlhe40

Gene Name

basic helix-loop-helix family, member e40

Synonyms

Bhlhb2; C130042M06Rik; Clast5; CR8; Dec1; Sharp2; Stra13; Stra14

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030103

Encoded Proteins

IDBP-174610

basic helix-loop-helix family, member e40

IDBP-624394

basic helix-loop-helix family, member e40

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl\'s transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:108660629-108666925

Strand

Forward strand

Band

Transcripts

ENSMUST00000032194	ENSMUSP00000032194
ENSMUST00000166346
ENSMUST00000163617	ENSMUSP00000132157

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding
GO:0043426	MRF binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007623	circadian rhythm
GO:0009416	response to light stimulus
GO:0032922	circadian regulation of gene expression
GO:0043153	entrainment of circadian clock by photoperiod
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated