Version 5.4
Mus musculus Gene: Obfc1
Summary
InnateDB Gene IDBG-174674.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Obfc1
Gene Name oligonucleotide/oligosaccharide-binding fold containing 1
Synonyms 0610009H20Rik; 2310057J23Rik; AAF-44; AAF44; AI413458; RPA-32
Species Mus musculus
Ensembl Gene ENSMUSG00000042694
Encoded Proteins
IDBP-174678
oligonucleotide/oligosaccharide-binding fold containing 1
IDBP-789569
oligonucleotide/oligosaccharide-binding fold containing 1
IDBP-789570
oligonucleotide/oligosaccharide-binding fold containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107960:
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47501033-47537507
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000049369 ENSMUSP00000040944
ENSMUST00000182873
ENSMUST00000182808 ENSMUSP00000138727
ENSMUST00000182431
ENSMUST00000182251
ENSMUST00000183004
ENSMUST00000182291 ENSMUSP00000138553
ENSMUST00000182654
ENSMUST00000182714
ENSMUST00000183283
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0043047 single-stranded telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0010833 telomere maintenance via telomere lengthening
GO:0045740 positive regulation of DNA replication
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
GO:0045111 intermediate filament cytoskeleton
GO:0070188 Stn1-Ten1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107960
View Gene Order
ENSBTAG00000015019
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_175360 XM_006526597 XM_006526598
OMIM
CCDS CCDS29892
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca