InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nfix

Summary

InnateDB Gene

IDBG-174687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfix

Gene Name

nuclear factor I/X

Synonyms

CTF; NF-I/X; NF1-X; NFI-X

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001911

Encoded Proteins

IDBP-174689

nuclear factor I/X

IDBP-213126

nuclear factor I/X

IDBP-261694

nuclear factor I/X

IDBP-261696

nuclear factor I/X

IDBP-534195

nuclear factor I/X

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008441:
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5\'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:84699876-84800344

Strand

Reverse strand

Band

Transcripts

ENSMUST00000076715	ENSMUSP00000076005
ENSMUST00000099070	ENSMUSP00000096669
ENSMUST00000109764	ENSMUSP00000105386
ENSMUST00000109762	ENSMUSP00000105384
ENSMUST00000148644
ENSMUST00000148746
ENSMUST00000132236
ENSMUST00000126806	ENSMUSP00000115691

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0021549	cerebellum development
GO:0021680	cerebellar Purkinje cell layer development
GO:0021707	cerebellar granule cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048708	astrocyte differentiation