Version 5.4
Mus musculus Gene: Scn3a
Summary
InnateDB Gene IDBG-174750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scn3a
Gene Name sodium channel, voltage-gated, type III, alpha
Synonyms Gm1000; Nav1.3
Species Mus musculus
Ensembl Gene ENSMUSG00000057182
Encoded Proteins
IDBP-174728
sodium channel, voltage-gated, type III, alpha
IDBP-174752
sodium channel, voltage-gated, type III, alpha
IDBP-534028
sodium channel, voltage-gated, type III, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153253:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:65457118-65567627
Strand Reverse strand
Band C1.3
Transcripts
ENSMUST00000100069 ENSMUSP00000097647
ENSMUST00000066432 ENSMUSP00000065023
ENSMUST00000155838
ENSMUST00000126837 ENSMUSP00000115321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
Biological Process
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0019228 neuronal action potential
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153253
View Gene Order
ENSBTAG00000019385
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2ASI5 Q3UF73 Q68V26
UniProt Splice Variant
Entrez Gene 20269
UniGene Mm.330256 Mm.395627
RefSeq NM_018732
OMIM
CCDS CCDS50596
HPRD
IMGT
MGI ID MGI:98249
MGI Symbol Scn3a
EMBL AJ810517 AK148881 AL772235 AL928621
GenPept BAE28688 CAH17961
RNA Seq Atlas 20269

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca