InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ehmt2

Summary

InnateDB Gene

IDBG-174783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ehmt2

Gene Name

euchromatic histone lysine N-methyltransferase 2

Synonyms

Bat8; D17Ertd710e; G9a; KMT1C; NG36

Species

Mus musculus

Ensembl Gene

ENSMUSG00000013787

Encoded Proteins

IDBP-174785

euchromatic histone lysine N-methyltransferase 2

IDBP-174787

euchromatic histone lysine N-methyltransferase 2

IDBP-174789

euchromatic histone lysine N-methyltransferase 2

IDBP-252605

euchromatic histone lysine N-methyltransferase 2

IDBP-541865

euchromatic histone lysine N-methyltransferase 2

IDBP-713183

IDBP-627858

euchromatic histone lysine N-methyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22412156

Ehmt2 catalyzes di-methylation of histone H3 at the promoter of interferon (IFN) and IFN-inducible antiviral genes as an epigenetic silencing mechanism in fibroblasts. Ablation of Ehmt2 results in phenotypic conversion to potent IFN-producing cells and renders resistance to RNA viruses.

InnateDB Annotation from Orthologs

Summary

PMID 22412156

[Homo sapiens] EHMT2 catalyzes di-methylation of histone H3 at the promoter of interferon (IFN) and IFN-inducible antiviral genes as an epigenetic silencing mechanism in fibroblasts. Ablation of EHMT2 results in phenotypic conversion to potent IFN-producing cells and renders resistance to RNA viruses. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204371:
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described. [provided by RefSeq, Jul 2008]
This gene is located in a gene cluster within the human major histocompatibility complex class III region on chromosome 6. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but recent publications show that there is only a single gene at this locus. The encoded protein is a histone methyltransferase, which may be involved in repression of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34898469-34914052

Strand

Forward strand

Band

Transcripts

ENSMUST00000078061	ENSMUSP00000077208
ENSMUST00000097342	ENSMUSP00000094955
ENSMUST00000013931	ENSMUSP00000013931
ENSMUST00000114033	ENSMUSP00000109667
ENSMUST00000146418
ENSMUST00000138500
ENSMUST00000150786
ENSMUST00000145624
ENSMUST00000124846	ENSMUSP00000121838
ENSMUST00000131915
ENSMUST00000137071	ENSMUSP00000134749
ENSMUST00000145201
ENSMUST00000124002
ENSMUST00000172921	ENSMUSP00000134089

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	25 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0046976	histone methyltransferase activity (H3-K27 specific)
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006275	regulation of DNA replication
GO:0006306	DNA methylation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007130	synaptonemal complex assembly
GO:0007281	germ cell development
GO:0007286	spermatid development
GO:0009566	fertilization
GO:0010424	DNA methylation on cytosine within a CG sequence
GO:0016571	histone methylation
GO:0018027	peptidyl-lysine dimethylation
GO:0034968	histone lysine methylation
GO:0035265	organ growth
GO:0045087	innate immune response (InnateDB)
GO:0051567	histone H3-K9 methylation
GO:0070734	histone H3-K27 methylation