Version 5.4
Mus musculus Gene: Cln6
Summary
InnateDB Gene IDBG-174956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cln6
Gene Name ceroid-lipofuscinosis, neuronal 6
Synonyms 1810065L06Rik; AW743417; D9Bwg1455e; nclf
Species Mus musculus
Ensembl Gene ENSMUSG00000032245
Encoded Proteins
IDBP-174958
ceroid-lipofuscinosis, neuronal 6
IDBP-539925
ceroid-lipofuscinosis, neuronal 6
IDBP-538768
ceroid-lipofuscinosis, neuronal 6
IDBP-537276
ceroid-lipofuscinosis, neuronal 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128973:
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:62838785-62852006
Strand Forward strand
Band B
Transcripts
ENSMUST00000034776 ENSMUSP00000034776
ENSMUST00000141821 ENSMUSP00000114283
ENSMUST00000138276 ENSMUSP00000117833
ENSMUST00000124984 ENSMUSP00000115675
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001573 ganglioside metabolic process
GO:0007040 lysosome organization
GO:0007042 lysosomal lumen acidification
GO:0007601 visual perception
GO:0008203 cholesterol metabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0031987 locomotion involved in locomotory behavior
GO:0044265 cellular macromolecule catabolic process
GO:0045862 positive regulation of proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128973
View Gene Order
ENSBTAG00000005565
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 76524
UniGene Mm.283636
RefSeq NM_001033175
OMIM
CCDS CCDS23267
HPRD
IMGT
MGI ID MGI:2159324
MGI Symbol Cln6
EMBL
GenPept
RNA Seq Atlas 76524

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca