InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Oxtr

Summary

InnateDB Gene

IDBG-175080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oxtr

Gene Name

oxytocin receptor

Synonyms

OTR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049112

Encoded Proteins

IDBP-175082

oxytocin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180914:
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:112473684-112489808

Strand

Reverse strand

Band

Transcripts

ENSMUST00000053306

ENSMUSP00000051132

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004990	oxytocin receptor activity
GO:0005000	vasopressin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding

Biological Process

GO:0001967	suckling behavior
GO:0001975	response to amphetamine
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0007613	memory
GO:0010701	positive regulation of norepinephrine secretion
GO:0014070	response to organic cyclic compound
GO:0021537	telencephalon development
GO:0030431	sleep
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0034059	response to anoxia
GO:0034097	response to cytokine
GO:0035176	social behavior
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0042711	maternal behavior
GO:0042713	sperm ejaculation
GO:0042755	eating behavior
GO:0043434	response to peptide hormone
GO:0044058	regulation of digestive system process
GO:0045777	positive regulation of blood pressure
GO:0048545	response to steroid hormone
GO:0048565	digestive tract development
GO:0051965	positive regulation of synapse assembly
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060137	maternal process involved in parturition
GO:0060206	estrous cycle phase
GO:0060406	positive regulation of penile erection
GO:0060455	negative regulation of gastric acid secretion
GO:0070371	ERK1 and ERK2 cascade
GO:0070474	positive regulation of uterine smooth muscle contraction

Cellular Component

GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005913	cell-cell adherens junction
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane